The SKP 1 - Cul 1 - F - box and Leucine - rich repeat protein 4 ( SCF - FbxL
نویسندگان
چکیده
Capucine Van Rechem, Joshua C. Black, Tarek A. Abbas, Andrew Allen, Claire A. Rinehart, GuoCheng Yuan, Anindya Dutta, and Johnathan R. Whetstine Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, 13 Street, Charlestown, MA 02129, USA. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Department of Biology, Western Kentucky University, 1906 College Heights Boulevard, Bowling Green, KY 42101-1078, USA. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, USA.
منابع مشابه
Degradation of the Neurospora circadian clock protein FREQUENCY through the ubiquitin-proteasome pathway.
Phosphorylation of the Neurospora circadian clock protein FREQUENCY (FRQ) promotes its degradation through the ubiquitin-proteasome pathway. Ubiquitination of FRQ requires FWD-1 (F-box/WD-40 repeat-containing protein-1), which is the substrate-recruiting subunit of an SCF (SKP/Cullin/F-box)-type ubiquitin ligase. In the fwd-1 mutant strains, FRQ degradation is defective, resulting in the accumu...
متن کاملA Comprehensive Analysis of Interaction and Localization of Arabidopsis SKP1-LIKE (ASK) and F-Box (FBX) Proteins
F-Box (FBX) proteins are encoded by a multigene family present in major lineages of eukaryotes. A number of FBX proteins are shown to be subunits of SCF complex, a type of E3 ligases composed of SKP1, CULLIN, FBX and RBX1 proteins. The Arabidopsis SKP-LIKE (ASK) proteins are also members of a family and some of them interact with FBX proteins directly. To clarify how FBX and ASK proteins combin...
متن کاملThe Role of FBXW Subfamily of F-box Proteins in Tumorigenesis
H. Inuzuka and W. Wei, SCF and APC E3 Ubiquitin Ligases in Tumorigenesis, SpringerBriefs in Cancer Research, DOI 10.1007/978-3-319-05026-3_2, © The Author(s) 2014 Abstract In the human genome, 69 putative F-box proteins have been identifi ed which could form a variety of different SCF type E3 ligase complexes to specifi cally target a wide range of proteins for degradation. F-box proteins can b...
متن کاملF-box proteins: the key to protein degradation.
The eukaryotic protein degradation pathway involves the ubiquitin (Ub) modification of substrates targeted for degradation by the 26S proteasome. The addition of Ub, a process called ubiquitination, is mediated by enzymes including the E3 Ub ligases which transfer the Ub to targeted substrates. A major type of E3 Ub ligases, the SCF (Skp-Cullin-F-box) complex, is composed of four major componen...
متن کاملF-box protein substrate recognition
Ubiquitin E3 ligases represent an increasingly diverse group of proteins whose precise biologic role still remains enigmatic. Of the SCF (Skp1-Cullin1-F-box) E3 ligase family, for example, only very few subunits from over 60 family members are well-characterized. The SCF apparatus contains a multi-subunit catalytic core consisting of Skp1, Cullin1 and the E2 ubiquitin-conjugating (Ubc) enzyme a...
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